Industry: Biomedical / DNA Sequencing / Nanotechnology
Challenge:
The client sought to enhance the performance of Cr-Au electrodes used in DNA sequencing, particularly to increase the surface area of gold for improved RNA bonding. Their goal was to achieve a significant improvement in electrode performance, specifically a 50-fold increase in surface area, to enhance the sensitivity and efficiency of DNA sequencing technology.
Image Description: Gold nanoparticles were coated onto Cr-Au substrates, using Nikalyte technology to create nanoporous gold electrodes for DNA sequencing.
Solution:
Nikalyte designed and fabricated nanoporous gold electrodes on Cr-Au coated glass substrates measuring 6x25mm. These electrodes were enhanced further with gold nanoparticles, which were coated on the substrate to provide additional surface area for better biomolecule bonding. Once the electrodes were created, they were successfully assembled into a flow cell for use in the sequencing system. This design targeted a substantial increase in capacitance and overall performance.
Results:
The gold nanoparticles coated on Cr-Au substrates and assembled into the flow cell resulted in a 100x increase in capacitance, significantly improving the electrical properties required for RNA bonding and detection. This advancement was a major step toward improving the sensitivity of DNA sequencing technology.
Note: Full details of the project and results are confidential, protected under an NDA.
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